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A combination of expletives meant to be said in a time of panic, fear, or when pissed off.
"Holy" can be left off or included. Examples of both are below.
When the cars came inches from colliding, Jeff screamed "HOLYFUCKSHITWHORE!!!" before passing out.

When Jane dropped a Dr. Pepper can on her toe, she yelled "Fuckshitwhore!" and mumbled incoherently as she limped away.
by Pyretta Blaze June 02, 2006