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1.
a term often used instead of and meaning "holy shit" either by a young person in front of there parents to avoid getting an ass whooping or by a young person in front of peers as a term of surprise, shock.
"holy moly did you see the speed of that car?"
by xman2007 May 08, 2006
 
2.
It means the same thing as holy shit or jesus christ, basically it's a muted and politically accepted reaction to seeing a gorgeous woman.
A ravishing woman walks into a room.
A guy looks at her and says Holy Moly look at her.
by Blake Southwood September 13, 2003
 
3.
A variation on the Mexican "Mole" sauce. The phrase was coined to describe a Mole sauce which was so purely hot that it cleansed not only your bowels but your soul as well. However over time the meaning changed to mean simply a frightfully shocking occurrence.
"This salsa will burn it's way in and out!"
"Holy moly!"
by the79bomb October 07, 2009
 
4.
A religious drug addict, especially one that cranks the beat up.
Father, you are one holy moly, AND I NEED THE CRACK ROCK.
by Mish July 01, 2004