1.a term of exclamation when you are fed up with all the stinkin fatass mother.......you get the idea. Fed up with anything would work i guess
2. another use is just like 'holy cow' except its 'holy kanoodle'
(kanoodle is a much cooler word)
1. Holy Kanoodle i'm gonna kill all these people!
2. HOLY KANOODLE! ARE YOU SERIOUS?!