Top Definition
The worst of all sexually transmitted diseases. The herpes simplex virus with added genetic coding from the gonorrhea bacterium, allowing it to invade CD4+ T cells and rewrite their tRNA to code for syphilis proteins. Can only be cured by a cocktail of paracetamoxyfrusebendroneomycin and Mad Dog 20-20.
Guy 1: Dude, I think I caught herpegonosyphilitis from those 5 hookers at my party.
Guy 2: Here, have some paracetamoxyfrusebendroneomycin and a fifth of mad dog.
by Colonel Obvious February 21, 2009

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