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4.
A combination of the four STD's Herpes, Gonorrhea, Syphilis, and AIDS. Commonly found in African American prostitutes, and large southern women.

Symptoms include: Itchyness, bleeding of the genetalia, and long term to permanate pubic baldness.
Doug: Wow, that chick has a ton of STD's!
Manny: Yea it must be herpagonosyphilAIDs.
by TiGoNThEGrEaT February 26, 2010
 
1.
A condition in which a person has multiple STDs. Usually acquired by promiscuous fucktards who refuse to use condoms during intercourse. Used to signify how nasty someone is.
I heard John got herpagonosyphilaids from all those hooknasties.
by koalaroo February 28, 2008
 
2.
a combination of herpes, gonorrhea, syphilis, and AIDS; usually aquired from extremely promiscuous/dangerous behavior
Rachel had fucked over seventy dudes, so naturally everyone assumed she had herpagonosyphilaids.
by R&B December 30, 2005
 
3.
What is contracted after one too many one-night-stands with less than well groomed members of the opposite(or same) sex.
An STD smorgasbord containing herpes, gonorrhea, syphilis, and AIDS.
Dude, I knew you shouldnt have gone to that orgy! Now you've gone and got herpagonosyphilaids!
by Jake Artsyboy August 23, 2008
 
5.
Coined by my old roommate, the term refers to the simultaneous contraction of humankind's most popular/common Sexually Transmitted Diseases.
That guy I banged last night was so skeezy, he for SURE gave me herpagonosyphilaids!
by Kate78 August 23, 2007