A combination of Herpes, gonorrhea, syphilis, and aids. Usually the first thing someone thinks of when they think about a really slutty girl/guy they don't like.
Guy - "Hey Suzy, do you know that hot chelsea chick that sits behind us in biology?"
Girl - "Yeah, she has Herpagonasyphilaids."
Guy- "No shit? So I should wear protection when I bang her?"
Girl - "gahhh.."