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1.
to leave; take off

especially when details of departure or destination are suggested more by circumstance than a schedule or itinerary.

common in the Midwest esp. Mi
Those two argue all the time but if I have to duck, I'm heading out!

or

We are going to the bar, wanna head out with us?

by miss elis March 31, 2008
 
2.
Equivalent to "get the fuck out."

Often used in conjunction with being "all set."
Ex. 1:
"This party is getting a little weird. I'm gonna head out."

Ex. 2:
"I'm all set on Bobby. He can head out."
by BarJen October 01, 2013