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1.
When a girl is sandwiched between two guys, and giving them each a handjob.
Hannah is such a slut, i saw her give a handwich at Luke's party.
by Tigerpants June 09, 2009
 
2.
The remaining odor left on one's hand(s) after eating a sandwich or hoagie or grinder or sub, etc.
Lou’s on 4th makes the best Pastrami and Kraut around, but watch out for the strong handwich it gives ya. You'll be smelling that after 2 days and 10 strong hand-washings!
by Sol Q May 24, 2006