A hand grenade is a melon flavored alcoholic beverage sold at Tropical Isles on Bourbon Street in New Orleans. Marketed as the strongest drink on Bourbon Street, it is the equivalent of about 4 1/2 standard drinks

The Ugly friend of the Hot Chick that you want to hook up with. Someone has to "jump on the hand grenade" so the other can get to the hottie.

When a session of fingering your girl starts to get a little dull, let it all end with a bang. Slip your fist inside of her vag, and without warning, extend all of your fingers as far as they can reach. The expression on her face should resemble some sort of surprise.

Mickey's Malt Liquor, sold in bottles which resemble a hand grenade.

When wishing to impose justice on a woman, clench the fist as if to punch something. With the fingers of the other hand, slightly part the lips of the woman's vag and thrust the clenched fist deep inside. This is the hand grenade, and is used around the world to evoke a mixture of both pain and pleasure.

Hand Grenade is the awesome Hedley song from the CD Famous Last Words

A simple cocktail of coke and vodka.

Take one can of coca cola, drink it down about a tenth of the way and apply vodka liberally (or to yuppie taste) into the can. As you get further down, add a little more, a typical hand grenade will have contained about 4 shots (and a good 2 others spilt on the floor) when drunkenly poured and drank correctly.

The term handgrenade comes about because as you top it up you should be left with a near pure shot of vodka with a tint of coke at the bottom, blowing you away.

Best enjoyed with a fine vodka like Absolut. Absolut with lemon if you're kind've fruity.