Top Definition
male ejaculate; semen

Can also be used as a verb
"Yo dawg, sorry I couldn't text you back, I was making hand sauce."

"We were playin' Rocket League the other night and were just hand saucing the fuck out of those nerds."
by Shrekkin' Nerds August 21, 2015
The slowly-built-up brownish filth that accumulates on items that come in contact with many different dirty fingers. Commonly found on that nasty 10-year-old keyboard you have to use at work, public restrooms, remote controls, etc. Source: overheard in local conversation
"I ain't touchin that nasty-ass mouse of yours until you clean that hand sauce off of it"
by jake5443 March 06, 2006
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