Top Definition
The slowly-built-up brownish filth that accumulates on items that come in contact with many different dirty fingers. Commonly found on that nasty 10-year-old keyboard you have to use at work, public restrooms, remote controls, etc. Source: overheard in local conversation
"I ain't touchin that nasty-ass mouse of yours until you clean that hand sauce off of it"
by jake5443 March 06, 2006
7 Words related to hand sauce

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