(noun): a jerk, an asshole, a real douchebag--an especially handy term to use when you cannot use the epithet you really wish to use (i.e. a jerk, an asshole, a real douchebag) because you are in the presence of children, grandparents, authority figures, what-have-you. Origin: Guy Smiley from Sesame Street, who was NOT an asshole.
Okay, who's the GUY SMILEY who ate the last Ho-Ho?" or "I'm going to be really late because some GUY SMILEY cut me off in traffic so close that my car flipped over and I'm sitting with my 3 year old niece in the car waiting for the cops.