To COMPLETELY dominate somthing or someone
I totally guffed you up
by DFG January 14, 2003
5 Words related to guffed
Top Definition
breaking wind, letting rip, farting
phewwww can you smell that i've just guffed!!!!!!
by marie August 05, 2003
to be completly off your face on weed

comes from south affrica
u look competly guffed
by wierd is a good thing February 10, 2005

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