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2.
To COMPLETELY dominate somthing or someone
I totally guffed you up
by DFG January 14, 2003
 
1.
breaking wind, letting rip, farting
phewwww can you smell that i've just guffed!!!!!!
by marie August 05, 2003
 
3.
to be completly off your face on weed

comes from south affrica
u look competly guffed
by wierd is a good thing February 10, 2005