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1.
The fat chick that hangs around with the hot chick. Usually requires a wingman to climb the back fence, distracting the orange ruffy enough for the sandlot kid to retrieve his baseball

The angrier the guard dog - the fatter the fatty
Nailed a hottie last night, couldn't have done it without Johnno climbing the back fence.

Angry, angry guard dog
by Ben November 18, 2004
 
2.
1: A girl's friends, who almost always make it uncomfortable to be around the girl you want to talk to. All girls have them, and they are a problem for most guys.

2: Dogs, usually Rottweilers or German Shepherds, used to guard prisons and other high security buildings.
"Hey, Terry, you should go talk to Maria"

"No way JT, she's got guard dogs like hell!"

"I'm almost out of jail! OH SH*T! I forgot about the guard dogs!"
by Phenomenal1 April 20, 2010
 
3.
Slang for a gat. Generally a handgun, or other concealable firearm.
Often used in conjunction with teeth.

Assumed to have originated in the Canadian west provincial drug trade.
Man, I got shitloads of teeth, but no guard dogs...how 'mi s'posed to protect my boys?
by Geth November 17, 2004
 
4.
One or several ugly women that seem to hang around attractive females, offering protection and an effective deterrent against hopeful males.
"Hey dude look at that hottie over there?"

"No chance mate you have to get past the guard dogs first!"
by Alex Tooth May 08, 2008