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5.
To go completely bat shit; driven to the brink of insanity.
"Man, if I have to hear Babci's story about how she beat up that guy in the bar in '43 and they rolled out into the street in front of the bus I'm gonna go guano"
by shannonkg May 25, 2007
 
2.
a substance composed chiefly of the excrement of seafowl and used as a fertilizer; aka bat sh!t
watch "ace ventura 2"
by snoopid September 13, 2004
 
3.
Guano mines as a source of nitrate, producing 84% of the world's supply of fertilizer, a $1.4 billion industry.
Guano. Hello. Does "poo" ring a bell?
by CartoonChess July 22, 2004
 
4.
literally meaning bat feces, it can be substituted for shit as a much cooler alternative
Holy guano! This place smells like guano!
by Tehpola June 27, 2004
 
6.
1. Avian fecal matter. In the 18th and 19th centuries, the North American Guano Company would send ships to south-Pacific islands to harvest the guan, which was used as fertilizer. (seriously!)

2. Bad news or something unpleasant and unflattering.
1. We used to have to import our <i>guano</i> from Mocronesia, but today we produce so much bullshit in Washington, that we no longer need the bird shit!

2. Wendy really dumped a load of <i>guano</i> on me when she said we were breaking up!
by Malcolm X-crement November 16, 2003
 
7.
Bat fecies.
I had to clean some guano of my car.
by mic March 16, 2003