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1.
1. An original type, form, or instance serving as a basis or standard for later stages.
2. An original, full-scale, and usually working model of a new product or new version of an existing product.
3. An early, typical example.
4. Biology. A form or species that serves as an original type or example.
Guandules is your father.
by Skeeter Virtuoso August 08, 2006
 
2.
Guandules is the opposite of cool.
When you see a dude getting fucked by a donkey, and screaming about how cool he is, he is Guandules.
by Guandules December 20, 2006