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An interjection used to exclaim surprise or astonishment. Has redneck-ish (and even sexual)connotations and is perhaps used mainly in rural America. Also known to be occasionally used by the Looney Toons cartoon character Yosemite Sam.
*at a small ranch in West Texas*

Jim Bob: Welp. Time to git down ta bizness an' work the ol' cow.

*suddenly sees two large overweight trespassing strangers doing something "suspicious" to one of his pigs*

Jim Bob: *gasps* Great horny toads, what in the Sam Hill h've you sum bitches bin doin' to mah prize hog!

Mark H. Proud Urban Dictionary Slang Author since February 2004.
by Mark H January 10, 2006

Words related to great horny toads

sam hill hillbilly holy cow holy shit judas priest redneck
1. Perhaps the most offensive exclamation in the human language.
2. Magnificent sexually excited amphibians
1. I shouted "great hornytoads" at a grocery store and got all these weird looks from people. Apparently they were pretty offended.
2. I don't want to go in that swamp, it's filled with great hornytoads.
by babaloulou December 01, 2003