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1.
To masterbate. Taken from the popular sketch comedy show Cheppelle's Show. The sketch refered to involved a man's Granny walking in on him masterbating in the bathroom.

Can be used as an exclamation to warn someone that you're spanking the monkey, or used as a verb.
Person 1: I'm hungry. I wonder what's in the kitchen...
Person 2: Granny don't!

Person 1: Where's Phillip?
Person 2: In the basement, probably having a "granny don't!"
by CaptainJonus May 03, 2006