Bay Area slanguage for Marijuana! LLE is pronounced "Yay" also known as LLEO which is pronounced: "Yayo". Lle is just the original Columbian spelling of the word. Anyways, the term Grandma Lle refers to Weed, Skunk, Haze, Kush, Jane, all that shit yadadamean, it's like a lleo high for grandmas and shit that don't really wanna get all gacked out can't stand the come down. Also refered to as Granddaddy.
"I'm off that henny and that grandma lle, As we speak..."
E-40 - Some song on My Ghetto Report Card (can't remember which)

"It's good, it's good, like that granddaddy."
-Keak Da Sneak on 'Tell Me When To Go'
by G-Blunted May 19, 2006

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