The physical, mental, and emotional condition one achieves through prolonged periods (generally multiple consecutive days) of sleep deprivation, malnutrition, & dehydration while under the influence of methamphetamines. Symptoms vary among individual users. However, common effects are delirium, schizophrenia, irritability, anxiety, mood swings, irrational & compulsive dis-assembly of household appliances & devices, chronic back & neck misalignment, and ill-advised barter of personal possessions (not necessarily belonging to the one affected by the condition).
The scatter-brained tweaker was obviously on a good one as he carpet surfed his car & sifted through the vacuum bag for meth on day five.
by Llenar13 January 30, 2010
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a sarchastic remark that can be used in response to anything said. Originated from Ross on friends.
"I hit him with my car"
"Umm Good One."
by kris mccarthy April 7, 2007
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A way of saying "good one" without it coming out rude
When someone tells a funny joke you would say "That was a good one!."

Oppose to a crappy joke you would say rudely "Good one!"
by sum-xo January 11, 2010
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This is an extremely sarcastic response to someones lame joke or foolish comment.

It is over emphasized greatly to stress the point that the comment or humor they made was in fact "NOT, A GOOD ONE."

Often will annoy or hurt the person it is directed at, but that was the point in the first place! Sometimes it is followed by the persons name to further cut them down as in " good one hank!"
Harold: She was asking me to go out sometime, I wasn't sure what to say?

Gary: you should have said, " I can't go out because I am a reverse vampire and the night kills me"...

( pause with no laughter)

Harold: Good One!

Gary: Shut up, your jokes are lameburgers too..

Harold: wow, another good one!

Gary: you're a jerk
by Randoni April 6, 2009
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the same as on one but for a longer period of time. i.e. five or more days.
He would have outran the cops but he was on a good one and it finally caught up with him.
by brandon's wife May 21, 2004
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to be really hyperactive usually enhanced by stimulants (caffeine, sugar, chocolate)
lil monster is on a good one
by skaterjack October 5, 2006
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when someone says something trying to be funny and it just makes them look stupid so you say it being sarcastic.
"last time i heard that i laughed so hard i fell off my dinosaur!" GOOD ONE!
by hot_sizzle November 22, 2009
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