After doing your substance of choice, the point of time between the high and the crash at which you've passed the point of no return, and no additional amount of substances will keep you going.
(Responsible partiers take note: it would be wise to NOT WASTE ANY MORE OF YOUR SHIT at this point, recognize it for what it is and call it game over already! You'll only be mad at yourself later, like on Day 3...)
I could rail that whole bag, but it won't help. I'm goin' down.