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1.
To attack either with words or physically, especially with a slashing knife. Rooted in the name of Orenthol James (OJ) Simpson, ex-football star, who allegedly slashed his wife Nicole Brown Simpson and her male waiter friend Ron Goldman to death.

Made famous in pop culture venacular by syndicated sports talkshow host Jim Rome.
Present Tense

Mike: Those guys look angry!
Tim: Yeah, Wayne has a knife. I looks like he's gonna go orenthol on Bobby!!!!!!!!

Past Tense

Mike: Look at Bobby's face!
Tim: Dang, Wayne went orenthol on Bobby!
by Montana2k October 08, 2005