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1.
Basically, means to just for the person to stop everything he/she is doing and find the nearest gun, point it under their chin and pull the trigger. That way they will no longer bother you and you can get some peace and quiet without their pure bullshit spewing from their mouths. If one continues you to harass you after you say this, you legally have the right to make them discover what your fist tastes like. They cannot sue you for any reason.
Latin origins of GO Fuck yourself:goeth fucketh yourselfus
 
2.
A command for someone to get lost (especially from the person that says it), usually as a result of extreme annoyance. Literally it means for them to masturbate themselves, so they aren't inclined to harrass and receive sexual pleasure from the person they are annoying. It's more stinging than "fuck off" because it implies that they could not or should not find anyone else to have sex with, so they need to use the self-manipulation.
"lol, looks like i beat you at WoW again..." "go fuck yourself"
by Mr. Zed September 10, 2006
 
3.
To tell someone to go away or to just leave you alone or never talk to them ever again.
PJ: Hey can i eat dinner at your house ?
AJ: yeah right, go fuck yourself.

ahhaha

COMEBACK: if your a male or female and an ugly opposite person of sex tells you to "go fuck yourself", you should reply :"I'd rather be fucking myself then fucking you". ahhaha
by jUiCY JAYDA September 17, 2007
 
4.
A command uttered usually after one has said something infuriating or offensive to you.
Some people ask me why I curse so much. I respond to these people by asking them to go fuck themselves.

"Why don't you watch your mouth?"

"Why don't you go fuck yourself?"
by Disasterpiece January 23, 2008
 
5.
When someone tells you to go fuck yourself, they are encouraging you to shove your penis up your own asshole by bending it backwards. Or, if you're a female, to grab the nearest phallic object(s) and penetrate your orifices repeatedly. The connotation is that you'll probably enjoy it and will stop annoying everyone.
Broke Ass: "Hey man, can I have one of your beers out of the fridge?"

Working Man: "Go fuck yourself."
by Sled Dog Fucker January 26, 2011
 
6.
1. Telling someone to go away
2. Telling someone to stop speaking, usually because they are making either negative or non-sensical comments
"Hey Choz...wasn't that you sister I saw working the corner the other day?" "Hey..go fuck your self!"
by Chozito July 04, 2004
 
7.
This is a common phrase, which people often over-complicate.

In fact, it means exactly what it says:

GO: Go, get hence, vacate yrself from here. And instead:
FUCK: Fuck, shag, accost, effect carnal intercourse with:
YOURSELF: You, yourself, you.
Whaddya mean what do I mean go fuck yourself?
Go. Fuck. Yourself.
You. Wanker.
Simple.
by Pipe Downn September 13, 2009