To stop trying to do something because you aren't getting what you want for your efforts
I wanted to get back with my ex but now I'm 'bout to give up the ghost.
Verb: to die in a submissive, peaceful fashion; or to die quickly, with finality, often brutally.
The freight-train barreling towards him, his foot still stuck, no time, he decided to give up the ghost.
to die, but can be used in reference to inanimate objects, ie, to stop working. In the case of subject matter, it means to reveal a secret, punchline, or conclusion.
Micah's birthday party is to be a surprise, but Brian might give up the ghost.
To die, break, stall, or malfunction.
I was late to work today because my car decided to give up the ghost.
to die, to succumb
If he does give up the ghost, love will never be the same.
To have sex with the same gender for the first time.
Jamal was in prison for 3 weeks and was forced to give up the ghost in the shower stalls.