look up any word, like cleveland steamer:
 
1.
have sex
Jenn: Wow, Anton is so cute. I totally want to give one to him.

Jess: You can't. He's gay.
by gsizm January 25, 2010
 
2.
Give one is a shortened phrase deriving from ' I don't Give a shit'. explained like:
Give one,
I couldn't give one
As in a shit
As in i couldn't give a shit
A: hey i read a great book on the history of bees
B: give one:)

A: you need to do the dishes
B: give one
by doodeyboob April 26, 2010