An order to a male or female who is being irritatingly feminine, whining too much, talking too much, talking about pillows or gossip girl.
A girlfriend is talking for over 2 minutes about pillowcases, pillow shopping and bed linen to her boyfriend 'GIRL DOWN! PLEASE GIRL THE FUCK DOWN!
A man surrounded by a crowd of women suggesting that we should skip dinner because we had a sandwich for lunch "GIRL DOWN I NEED MEAT!"
A New Orleans term used to tell someone to stop what they are doing because it is embarrasing them.
Or just to say "Cut it Out".
What's up with that ugly boy