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1.
To be in a bad mood; to be grumpy or unpleasant for no apparent reason.

The phrase refers to someone being in a bad mood from the moment they wake up.
1) Stephan, you sure are irritable today - did you get up on the wrong side of the bed this morning?

2) I feel awful. I must have gotten up on the wrong side of the bed this morning. On second thought, maybe it was all that champagne I drank last night!
by VAKI5 May 12, 2005