To do it. To go hard. To go balls deep. To accomplish something. To improve upon a life-skill. To party with the sickest group of skiers or snowboarders this planet has ever seen.
She's checking you out. Get after it.

You're gonna be late for your pap-smear? You better go get after it.

You didn't land that jump? You didn't get after it enough.
by Spartan Ski Club October 21, 2011
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(v.) 1. To exert a great deal of effort in pursuance of some worthy goal 2. To perform coitus in a manner satisfactory to both (or all) parties involved
"Get after it dude!"

"Sorry man, I can't go to the hookah bar tonight, I've got to get after it with my girlfriend."
by Dareh Meyod August 13, 2009
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When a group decides they are going out HARD for a night of drinking they are said to be, "getting after it"
Dude, I've made an executive decision. It's been a long week and we ARE getting after it tonight.
by Andrew1122 February 27, 2008
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To aggressively get fucked up. To go big. To consume party drugs and alcohol in an effort to become extremely wasted, yet still fired up enough to stay up late.
by partyboysf March 31, 2007
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taking it to the max, abusing substances to the point of annihilation, 6/24/10
Wow, we were definitly getting after it last night. I woke up in a field wearing only a burger king crown.
by Big B 143 June 25, 2010
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1.The act of finding any slut that wants the dick

2.Do work
"That bitch just eyefucked the shit out of me, time to get after it."
by Ryan O'Rourke November 22, 2008
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