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1.
Clinical term for a person who is confused about which gender they are and is abnormally sexually attracted to the same gender as them.
Look at those two gender challenged males kissing each other.
by BWM January 23, 2008
 
2.
General term for a person who does not display traditional gender identity and is sexually attracted to the same gender.
Sylvia and Josephine are gender-challenged, and very much in love.
by Aleyah Lepidus July 18, 2013