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28.
When someone's dead, or too messed up to go on living a normal life.
-You hear about Eddie?
-Yeah I heard he od'ed on some bad coke.
-It's game over man.
by david k February 28, 2005
 
1.
The situation you are in if your dropship crashes and leaves you stranded on a planet full of nasty extra terrestrials.
I guess this is it, man, I guess we're pretty fucked, game over, man, game over!
by Zalis August 05, 2004
 
2.
when you get married
When he got married, it was game over
by Bryan Pend October 04, 2007
 
3.
A sure sign that the game just kicked your ass...
I love the game over music for Final Fantasy 7, its just so... sad!
by Rimpala January 26, 2007
 
4.
The alternative to You Are Dead! in games that are not Resident Evil
Game Announcer Voice:Game Over

Gamer:Damn i died again

or

Screen Reads: You Are Dead!(in Blood)

Gamer:(screaming) I know damnit
by Chris Duett November 06, 2007
 
5.
a situation has ended unsuccessfully
If he gets away, it's game over for the credibility of the police chief.
by The Return of Light Joker January 29, 2009
 
6.
when u have lost the game usally runing out of lives.
last guy danm i died
GAME OVER
by bob December 08, 2003
 
7.
when youre trying to holler at a girl but you do something to totally ruin your game
i approach sandy with a drink in hand and end up tripping and spilling half the drink on her shirt.. my friends greet me with a "game over" when i return
by bay resident December 07, 2005