Fucking ugly piece of shit. Example: your dog, your mother, your 5th grade science teacher.
"Wow Bob ... you are just one FUPOS!"
"Your face is a FUPOS!"
"FUPOS fucker!"
"Rachelle, your car is a FUPOS!"
by Megroxorz January 20, 2008
Top Definition
Fucking Useless Piece Of Shit
The clerk behind the counter was such a fupos, he couldn't even make change for a twenty dollar bill.
by JannyGurl May 04, 2006
Fucked Up Piece Of Shit
Damm... Windows XP is a FUPOS!
by maximo_41 September 27, 2005
Fuck U Piss Off

(Fuck) (Fuck you) (Piss off)
Person 1: hey nice haircut

Person 2: fupo

Person 1: No need to get mad.
by Moosenator May 16, 2016
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