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1.
Unnaturally large number of siblings born at one (i.e., quadruplets, sextuplets, septuplets, octuplets) created by the abuse of reproductive technology (such as taking too many fertility drugs, implanting multiple embryos). Humans bodies are not built for litters of more than three, and these unfortunate kids are always born prematurely, usually suffer chronic health and developmental problems their entire life, and often die.
Also known as "freaklitters"
"Did you hear about that California woman who's brought her spawn total up to 14 by giving birth to another freaklitter? Those poor fuctuplets"

by ratscabies February 02, 2009
 
2.
The type of friends who are so close they seem like brother and sister, etc. -
until they sleep with each other.
Those guys are sleeping together? That's so wrong! They're like twins - I guess that makes them fuctuplets.
by Walking Dictionary Man November 15, 2004