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1.
Viciously and relentlessly attacking someone, usually to the point of visible injury.
1. Beth: "Jim just punched and tackled the shit out of Joe!"

John: "Oh shit, he's fucking him up!"

2. Dashie: Sir, listen, I don't have beef with you- *gets attacked* he's fucking me UP!

3. "Damn, I got an F on my Science exam. I feel like fucking someone up."
by The Master of Karate March 25, 2014