Top Definition
/v/ to disturb a second person's situation, belongings, or bodily person; to mess up another's nest, home ground, domicile or living situation through intentional or callous disregard; to cause a second person inconvenience, discomfort, or unwanted intrusion.
Jules: "That's cool man. We' don't wanna fuck up your shit."

Jimmie: "You don't wanna fuck up my shit? Well, you're fucking up my shit right now! And you'll be fucking up my shit BIG TIME if Bonnie get home. So you got to make some calls? You gotta call some people? Well do it!"

"Pulp Fiction" (1994)
by Billy Beck O'Hannity April 07, 2010
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