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1.
Sarcastic way of saying that something has gone wrong. Similar to the tooth fairy, but the fuck up fairy leaves mayhem instead of money.
It looks like the fuck up fairy came to visit - Milton crashed the system again.
by raven lunatic October 11, 2007
 
2.
An event or action which takes a turn for the worst.
Christ, the Fuck Up Fairy made a visit there.
by Rusty Jeffears September 19, 2008