2) To shoot someone in the head with a .45 caliber round or higher and brain matter explodes out of the bullet holes.
3) To be really high and have your dome all fucked up.
2) "If you dont shut the fuck up, I'm gonna pull out my .45, and fuck yo fuckin' dome! (Gunshot) Oh, fuck dome!"
3) "Oh, fuck my dome, I'm so high! Fuck dome."