Usually also implies addiction to the attendant abuse lifestyle that often bridges over into stimulant, (methamphetamine etc.) opiate (heroin, oxycontin etc.) and certainly sedative use.
usually found in a position of selling one or more of these compounds and/or other drugs to further support this lifestyle.
not necessarily a term of disparagement.
however the term usually implies a either a careless disregard towards anything beyond the goal of remaining buzzed as long as possible,
or it may imply and make fun of certain frequent effects of long-term dissociative abuse obeserved in the personalities of users.
thus it tends to suggest one is perpetually "fried" which by the connotation alone certainly does not convey the outward appearance of responsibility, enlightenment or overall enjoyability of a persons particular intoxicated state or its outward manifestations to others.