Fret lube is using the oil from your forehead or nose to lube up the buttons on a guitar hero/rock band guitar for faster playing.
Rock Band Player 1: Damn, I can't hit that green/red to blue/orange transition.
Rock Band Player 2: Dude, use some fret lube on that shit and shred it up!
by doubleu January 12, 2009

5 Words Related to fret lube

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