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To be defeated or beaten on many levels in many facets of life including but not limited to sports, school, and fisticuffs.
The inability to succeed at anything despite enormous effort.
Jane: Last week Bobby spent 24/7 studying for his Biology final and he still failed.
Alex: I know. Even the kid with a 65 IQ topped his score. He has a major case of Foot-In-Ass Disease.
by OneLostChapter February 14, 2008

Words related to foot-in-ass disease

ass disease feet foot mouth