Top Definition
To be defeated or beaten on many levels in many facets of life including but not limited to sports, school, and fisticuffs.
The inability to succeed at anything despite enormous effort.
Jane: Last week Bobby spent 24/7 studying for his Biology final and he still failed.
Alex: I know. Even the kid with a 65 IQ topped his score. He has a major case of Foot-In-Ass Disease.
by OneLostChapter February 14, 2008
5 Words related to foot-in-ass disease

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