fo shizzle my nizzle translates into "I will definitely acquiesce indubitably in the said activity such as drinking cool aid, grape soda, orange soda, KFC, watermelon, waffles, and various other food items".
Boo: Yo, would you like to participate in the consumption of Kentucky Fried Chicken, while consuming a 40 oz alcoholic beverage in the back of my vehicle that has the bass so far up that whenever I commute near a seismographic station, there seems to be a 10.7 on the Richter scale in Ethiopia.
La Fawnda: Fo shizzle my nizzle.
Boo: Well, that sounds swell to me. Let us hop in and endear in the lovemaking in the opposite sex.
by kevk77 March 15, 2009

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A modernized and extended version of the infamous Shakespearean Hamlet line, "To be ... or not to be?"
"Fo' shizzle ... o' no' fo' shizzle? Dat be the quizzle, my south-central British nizzle."
by HootieFoo June 05, 2003

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for sure my African American friend; popularized by Snoop Dog, but originating in African American communities to accommodate rhyming words which didn't have enough syllables
Alicizzle izzle blizzle than yizzle.

This new doggyfizzle televizzle gon' be off the hizzle, fo shizzle my nizzle
Translation: This new Snoop Dogg television show is going to be off the hook (meaning great), for sure my negro
by thebeautifulone May 04, 2009

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slang for "for sure my n*****"
Tyler: do you wanna go to the movies tonight?

Lydian: fo shizzle my nizzle
by Lydian Beck April 09, 2008

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Several people on here claim this has been "shortened" to
"fo' sheazy my neazy"
In what way is that supposed to be shorter?
Fo' sheazy my neazy queezy. Shizzle nizzle fissle wizzle. Wuzzles and noozles and snuggle wuggles. I do not like green eggs and ham, I do not like them sam I am.
by Russ March 11, 2003

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gangsta slang.

'izzle' replaces the end of some specified words.
"foshizzlemynizzle"

yo fo shizzle my nizzle in the hizzle.

yes - for sure my fellow black man, in the house.
by [NaZ] February 03, 2009

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An abbreviation of the Latin phrase, "For Shegro, My Negro."

Although modern linguists are unclear on the definition of the word 'Shegro', it is widely believed that it is related to the worship of the Roman Goddess Goddamnatsonehugebitchia. Certain daily activities were thought to cause the goddess to increase further in size; therefore, these activities were conducted 'for shegro.'
"Yo, you wanna go to the liquor store for a fifth of cat piss?"
"Fo' shizzle my nizzle!"

(Or, from the ancient Latin)

"Come hither, O Dumbassitus Putridus! Let us away to the market of bottled lusciousness!"
"For shegro, my negro!"
by Professor Eunoam DeRunque September 07, 2015

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