22
1. A polite and well meaning colloquialism. This phrase gained popularity when famed rapper/pornographer/movie star Snoop Dogg started using it and other words containing the suffix "izzle" or "izzy."

2. To informally aquiesce or agree with someone whom you consider an affable peer.
My friend Tim was like, "Whassup Dog, are you going to the game tonight?" I responded "Fo' Shizzle my nizzle" in the pitch of a tenor.
by Barry February 12, 2004
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23
An abbreviation of the Latin phrase, "For Shegro, My Negro."

Although modern linguists are unclear on the definition of the word 'Shegro', it is widely believed that it is related to the worship of the Roman Goddess Goddamnatsonehugebitchia. Certain daily activities were thought to cause the goddess to increase further in size; therefore, these activities were conducted 'for shegro.'
"Yo, you wanna go to the liquor store for a fifth of cat piss?"
"Fo' shizzle my nizzle!"

(Or, from the ancient Latin)

"Come hither, O Dumbassitus Putridus! Let us away to the market of bottled lusciousness!"
"For shegro, my negro!"
by Professor Eunoam DeRunque September 07, 2015
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24
Archaic phrase used by African American slaves since the 17th century. A corruption of 'For shine his hall, my knees ill' it was used as a greeting by slaves who had to polish the floors of colonial mansions. Later became an unrelated greeting.
'Missie, missie - yo massah done made me polish dat whole corridor, an it done made my knees hurt terrible - fo' shizzle ma nizzle, an no mistake!' from 'Gone With The Wind' by Margaret Mitchell.
by Anonymous June 26, 2003
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25
A slightly aborted version of a declined McDonald's slogan:
Hamburglar: "Come robble my knobble."
by WASTELY March 16, 2003
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26
fo shizzle my nizzle, or fo hizzle my wizzle, tranlates to: for sure, my nigger OR for sure my white-nigger. its mostly used by snoop dogg, dr dre, and eminem.
jay-z: "fo shizzle my nizzle used to sribble down in v.a"
by niggerina_hannah August 19, 2006
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27
hey johhny yo wanna go to da movies?
fo shizzle my nizzle
by James Bamford September 09, 2008
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28
The mean of Fo Shizzle My Nizzle is For sure, my nigger. often used when a Gangster or some sort of black person (or in some rare cases a white person) says it to his friends to make him seem cool or "gangster"
Rick: you sup joe
Joe: nutt'n much you?
Rick: same.... Oh shit its billy i hate that fag...
Billy: Yo Fo shizzle my nizzle dog
by Nomad guy February 01, 2009
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