Other words can also be "izzled". For example: "What's the dizzle?" is: "what's the deal?" Try it yourself but don't get carried away 'cause you're really gonna make a fool out of yourself...
While originating out of hip-hop culture, this phrase has been overused to the point of triteness. Its most famous usage is
Rich black man in response: "I concur with you whole heartedly my fellow African brother."
Ghetto black man: "..."