Generally means that the person saying it, is a twat
Hey! fo shizzle my nizzo biotch mo fo uhhmmmmmmmm. sup girlfriend?
by pea fan September 15, 2003
Phrase denoting agreement, most commonly used by the Negro population, but increasingly poular with the white-boy population e.g. Justin Timberlake.
Damn that girl fine!

Fo shizzle my nizzo!
by Stu Hughes September 15, 2003
for sure my nigga
"you wanna run a train on this whoa?"
"fo shizzle my nizzo!"
by ryan September 15, 2003
"For sure, my ni**er."
"Definitely, my good friend."
"Y'all headin' ta Tre's BBQ?"
"Fo shizzle my nizzo, that shit's gonna be off the heezy fo sheezy."
by Whitey September 15, 2003
The breakdown to this is the expressor to the expressee: shizzle my nizzo! This means putting action upon any object. Shizzle is the verb and Nizzo is the object of the verb. The expressor is asking the expressee to "do something to something"! Whatever it is and to what is up for purely speculative interpretation and depends on the linguistic conditions and the situational environment of the moment.
Lord girlfriend, I haven't seen you for so long. Come over here and "shizzle my nizzo"!
by Merrily McCarthy September 15, 2003
playful baby sextalk to perform foreplay on the clit with your nose
i proper snizzled her nizzo last night,
should have heard her moan!
by zabba September 15, 2003
For sure my nigger.
Dr. O: 'Hey Millsy, you goin' to the show?'

Millsy: 'Fo shizzle my nizzo!'
by Millsy September 14, 2003

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