look up any word, like dirty sanchez:
 
2.
Fo(Fo) sho(Shizzle) ma(mah) nigga(nizzle)
and to the white man that means
For(fo) Sure(shizzle) my(mah) African American (Nizzle)
Old Lady: fo shizzle ma nizzle
Snoop: for your information Nizzle does not mean neighbor
by luda June 05, 2004
 
1.
"fo shizzle ma nizzle" is a bastardization of "fo' sheezy mah neezy" which is a bastardization of "for sure mah nigga" which is a bastdardization of "I concur with you whole heartedly my African American brother"
see what I mean man?
fo shizzle ma nizzle
by John June 23, 2004
 
3.
"fo shizzle mah nizzle" is a bastardization of "fo sho mah nigga" which is a bastardization of "for sure my nigger" which is a bastardization of "i concur with you wholeheartidly my african american brother"
ghetto person 1- "dat gurl at dat bbq wuz wak son"
ghetto person 2- "fo shizzle mah nizzle!"
me- you're lame.
by rap sucks..misfits rock March 09, 2006
 
4.
Damn right, my African American friend/brother.
For sure, mah nigga.
Correct and right, my Afro-American friend.
Snoop:''That vanilla face sure thinks he is the shizzle''
Dre:''Fo' shizzle mah nizzle''

Snoop:''Eminem is a puff''
Dre:''....Fo' shizzle mah nizzle''
by Hectecopykizzle October 14, 2006
 
5.
Ebonic rhyming of "For sure, my nigger!"
Form of agreement among blacks.
Brutha #1: "Let's go get some fine boo-TAY!"
Brutha #2: "Fo shizzle mah nizzle!"
by TranslatorHater October 16, 2012
 
6.
For sure / of course
You wanna play some b-ball?
Fo shizzle mah nizzle
by Bj February 17, 2003
 
7.
Slang for 'For Real My Nigga'
You is fo shizzle mah nizzle wizzle
by Paul April 27, 2004