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1.
the female dressed lesbian in a relationship or group...

I STILL KNOW THIS IM GAY
Look at that feme...
by Megan April 26, 2004
 
2.
When you are a guy and you have a friend that is a female version of yourself, she is your Feme.
My friend Kim is the same person as me but a girl. She is my Feme.
by Jager-Bomber March 20, 2010