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1.
the process of leaving groups that you have been in too long/don't like anymore
dude your still in that group? you need to do some facebook cleaning
by Harrison Schroeder March 14, 2008
 
2.
The process of deleting "friends" from one's Facebook list.
Brian: I have like 1000 friends

Trent: I hope you're exaggerating...Dude, you need to do some Facebook cleaning

Brian: Truer words have yet to be spoken.
by Brorack Brobama February 10, 2010