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it means, for sure my nigger.
not sure why snoop dog ever said it, or why america adopted it, because a few years ago that term was degrading... and wait, it still is today.
dude #1: damn her ass is fine.
dude #2: f'shizzle my n'izzle.
me: wtf.
by my_glasses_ are_dirty January 22, 2006
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a word used by african american "brothers" to sound "gansta" in their "hood" because they really aren't. they just like to feel blacker than everyone else. its a "who has more welfare checks" game.
some ghetto rat/and/or/wannabe(god knows why) : f'shizzle my n'izzle, homeslice g dawg nizzle bizzle shizzle up the hiz nizzy' G.

non ghetto rat : *confused angry insulted homocidal look*
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DUH! It means for real my nigga.
Hoodraddish: Man, that girl is a strait up ho.
Cornstalk: f'shizzle my n'izzle.
by Gangsta Cornstalk December 13, 2005
55 155