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It started as a word used by The Surenos, a mexican gang,
since ese is how you pronounce the letter "S" in spanish, that is what they called each other. Nowadays, It is used by a lot of mexicans. It would be used by surenos like the word homie, or friend.
Sureno: Ey ese letz jump dat chapete over there
Sureno 2:iight ese letz go!
by MRJoker13 January 20, 2010
Group of people in Suffolk, New York. Often regarded as a gang but most members do not believe this. Activities include minor graffiti, "jackass" style video making, and some members take part in drinking, smoking, pills, etc. during parties which are thrown at various abandoned buildings. Wear purple bandannas tied around wrist or in back left pocket; which is why it is seen as a gang movement. But the bandannas are just a style adopted by the group.

Many locals have been starting trouble with them for unknown reasons.
bill: yo you see all that eSe graffiti on the building in the woods?

mike: yeah i saw it, its okay but they need to add more designs.

ese kid: imma fix it up when i cop some spray.
by LongwoodD00d December 31, 2009
a derogatory, stereo-typical reference made about or towards persons of Latin descent due to having or displying or pursuing poor taste, language, character, or product; A Latin equivalent of "Ghetto."
That car is so ese-looking. You can't be ese all your life.
by Whatever, aye! January 30, 2011
The last fold of skin on an uncircumcised penis.
The Mexican got an infection from getting his esé caught in his zipper.
by CajunCuntKiller May 21, 2011
misunderstood compatriot.
Who you trin’ to get crazy with ese (my misunderstood compatriot)? don’t you know I’m loco(just plain silly)?
by samuel clearbottom November 10, 2007
ese is a spanish word wich means "that one" but young mexicans have changed it meaning for "you"
it has nothing to do with surenos.
ese hombre es feo
that man is ugly
by El Padrino August 03, 2007
Linguistically, this word has a complex origin. In simplest terms, "ese" is derived from the Greek "es" meaning "is" and "e" meaning one of Spanish-American heritage. In more complex terms, the word is derived from the Latin "E", meaning "referencing one who is believed to be spanish" and "se" meaning "american".
"You're going down, ese." - Pearl
Ricardo: "Yo ese, good to see you made it 'cross the border."
by Bilqis Shambles September 28, 2007