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8.
The Designated (/Dumb) Ugly Fat Friend.

The cock-blocking friend of the hot chick you're trying to hook up with, often the target of the wingman.
I was totally in with this chick and then her D.U.F.F. totally cock-blocked me!

-or-

I'll take her, while you distract her D.U.F.F.!
by Victory2FuManchu September 07, 2006
98 45
 
9.
a teenage pop star with absolutely no talent.
hillary duff sucks
by hillary's ex April 12, 2004
311 258
 
10.
v. the act of punching someone in the face.
"Yo did you see Hilton duff Chino in the face"

"Chino is bleeding because he got duffed so hard"

"Some would should duff that kid, Chino, in the face"
by Douch B. September 27, 2007
80 40
 
11.
Literally stands for Designated Ugly Fat Friend. This is the bitch who comes out of no where to cockblock you when you are about to get a chick home with you. She is often recognizable by her fat ass, bad hair and sour disposition. Her main goal of the night is to fend off any advances on her friend so she will have company at the diner when she is stuffing her fat face with an omelet and a side of disco fries while she bitches about anyone and everyone. The D.U.F.F can be defeated with a high level wingman, but you will be expected to return the favor; a job not for the faint of heart. A naked D.U.F.F often smells like a box of crayons.
"Dude, I was about to bag this chick, but then her army of D.U.F.F's came out of no where and pulled her away. She must be a Volleyball player!"

"Did you Fuck the chick at the party?"
"No Fuckhead, I got Duffed!"
by LexDimonds July 31, 2009
45 7
 
12.
The unattractive girl that a hot girl keeps around to make herself and her friends look better. Stands for "Dumb Ugly Fat Friend". THe DUFF tends to be a cockblock or a third wheel. See also "Grenade".
Why do I always get stuck with the DUFF?
by G. Sherman August 11, 2003
124 90
 
13.
Bottom; bum; posterior; arse.
Get off your duff and help me with these dishes!
by Anonymous January 03, 2003
90 65
 
14.
A brand of cool US Skate shoes.
Yo man, you see those dope Duff Roadrunners? Way Fresh!!
by PHIVOLCS March 24, 2004
29 10