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92.
Generic term for beer. Originates from The Simpsons cartoon series, where Duff is the brand of beer characters drink.
"Pass me that duff". "You bring the weed and I'll bring the duff!"
by Karl Steiger January 31, 2004
 
93.
D-dumb
U-ugly
F-fat
F-friend

or

D-dumb
U-unreasonable
F-fuck
F-face

Go with it as you wish.
Snooki: "Oh my God. What a D.U.F.F.!"
Deena: "I know, right? Totally a duff."
by Smigslovesyou101 March 27, 2011
 
94.
1. Dumb Ugly Fat Fuck
2. Designated Ugly Fat Friend (the less harsh defintion)
That we-gotta-go-girl is such a D.U.F.F.
by cchriss92 July 26, 2007
 
95.
D.u.f.f- Dumb Ugly Fat Fuck, only used with girls but can be used with guys if necessary.
That girl at that lunch table eating jello is a fucking duff
by Kevin Derr April 25, 2007
 
96.
The Dumb Ugly Fat Friend. Every hot girl has one, and their objective is to cock block all the guys. And for every DUFF you need a grenade and thats ur friend that would try to hit anything.
WOW! that DUFF's a bitch.
by ATICUS September 11, 2006
 
97.
Designated Ugly Fat Friend/Designated Ugly Fat Fuck/Dumb Ugly Fat Friend

The infameous beer that Homer Simpson drinks on The Simpsons

a teenage pop star who has some talent but is over shadowed for being a "poseur"
That girl is a TOTAL DUFF

Homer Simpson always drinks Duff beer.

Hilary Duff is alright but everyone calls her a "poseur"
by Mike October 12, 2005
 
98.
Designated ugly fat friend. The girl (or guy) in a circle of friends who is usually the least attractive in the group. Usually the one who provided the ride, designated friver or paid cover charge for the others.
Kim on Moesha is the DUFF.
by at November 29, 2005