from the movie of the same name, a person who gets their high by way of prescription drugs, most likely obtained illegally.
"Most people don't know how they're gonna feel from one moment to the next. But a drugstore cowboy has a pretty good idea. All you gotta do is look at the labels on the little bottles.
by all for one one for all July 13, 2004
Drugstore cowboys originally referred to actors dressed as cowboys who could be seen daily at the drugstore coffee counters near the Hollywood studios after unsuccessfully trying to get parts as extras in the morning's open call.
Mavis couldn't get her morning cup of coffee and danish at Schwab's on her way to work because of the crowd of drugstore cowboys hogging the counter.
by Studio Tex March 23, 2006